兔抗ABL1(Phospho-Tyr245) 多克隆抗體

Background:

This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function.

Applications:

WB

Name of antibody:

ABL1(Phospho-Tyr245)

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 245 (T-V-Y(p)-G-V) derived from Human c-Abl.

Full name:

ABL proto-oncogene 1, non-receptor tyrosine kinase

Synonyms：

ABL; JTK7; p150; c-ABL; v-abl; c-ABL1; bcr/abl

SwissProt:

P00519

WB Predicted band size:

123 kDa

WB Positive control:

c-Abl Insulin treated K562 cells lysates

WB Recommended dilution:

500-1000