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  • GDNF抗原(重組蛋白)

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    • 品牌 : 通蔚生物
    • 目錄號 : TW11168
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
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中文名稱:GDNF抗原(重組蛋白)

英文名稱:GDNF Antigen (Recombinant Protein)

儲      存:冷凍(-20℃)

相關(guān)類別:抗原

概述

Fusion protein corresponding to a region derived from 20-211 amino acids of human GDNF


技術(shù)規(guī)格

Full name:

glial cell derived neurotrophic factor

Synonyms:

ATF1; ATF2; HSCR3; HFB1-GDNF

Swissprot:

P39905

Gene Accession:

BC069369

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease.