小鼠抗NR1I3單克隆抗體

Background:

This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.

Applications:

WB, IHC

Name of antibody:

NR1I3

Immunogen:

Fusion protein of human NR1I3

Full name:

nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 1

Synonyms:

CAR; CAR1; MB67

SwissProt:

Q14994

IHC positive control:

human colon tissue

IHC Recommend dilution:

25-100

WB Predicted band size:

40 kDa

WB Positive control:

HepG2, SVT2, A549 and COS7 cell lysates

WB Recommended dilution:

200-1000