兔抗GCSH多克隆抗體

Background:

Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the H protein, which transfers the methylamine group of glycine from the P protein to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH). Two transcript variants, one protein-coding and the other probably not protein-coding,have been found for this gene. Also, several transcribed and non-transcribed pseudogenes of this gene exist throughout the genome.

Applications:

ELISA, IHC

Name of antibody:

GCSH

Immunogen:

Fusion protein of human GCSH

Full name:

glycine cleavage system protein H

Synonyms:

GCE; NKH

SwissProt:

P23434

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer and Human colorectal cancer

IHC Recommend dilution:

50-200