兔抗DAB2多克隆抗體

Background:

This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

DAB2

Immunogen:

Fusion protein of human DAB2

Full name:

DAB adaptor protein 2

Synonyms:

DOC2; DOC-2

SwissProt:

P98082

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human tonsil and Human thyroid cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

82 kDa

WB Positive control:

Hela cells

WB Recommended dilution:

500-2000