GRB2抗原（重組蛋白）

Full name:

growth factor receptor-bound protein 2

Synonyms:

ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2

Swissprot:

P62993

Gene Accession:

BC000631

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.