ELISA試劑盒

PCR試劑盒

生化試劑盒

細胞系

細胞庫

基礎培養(yǎng)基

完全培養(yǎng)基

原代細胞

細胞專用培養(yǎng)基

菌株

生化試劑

病理染色液

科研抗體

HIF1AN抗原（重組蛋白）

規(guī)格：

數(shù)量：

購買數(shù)量

價格：￥

中文名稱： HIF1AN抗原（重組蛋白）

英文名稱： HIF1AN Antigen (Recombinant Protein)

別名： FIH1

儲存： 冷凍（-20℃）

相關(guān)類別：抗原

概述

Full length fusion protein

技術(shù)規(guī)格

Full name:	hypoxia inducible factor 1, alpha subunit inhibitor
Synonyms:	FIH1
Swissprot:	Q9NWT6
Gene Accession:	BC007719
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively.

ELISA試劑盒

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