中文名稱:MYOT抗原(重組蛋白)
英文名稱: MYOT Antigen (Recombinant Protein)
別 名: MFM3; TTID; TTOD; LGMD1; LGMD1A
儲(chǔ) 存: 冷凍(-20℃)
相關(guān)類別: 抗原
概 述:
Fusion protein corresponding to a region derived from 299-498 amino acids of human MYOT |
Full name: |
myotilin |
Synonyms: |
MFM3; TTID; TTOD; LGMD1; LGMD1A |
Swissprot: |
Q9UBF9 |
Gene Accession: |
BC005376 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
This gene encodes a cystoskeletal protein which plays a significant role in the stability of thin filaments during muscle contraction. This protein binds F-actin, crosslinks actin filaments, and prevents latrunculin A-induced filament disassembly. Mutations in this gene have been associated with limb-girdle muscular dystrophy and myofibrillar myopathies. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. |