中文名稱:PPOX 抗原(重組蛋白)
英文名稱: PPOX Antigen (Recombinant Protein)
別 名: protoporphyrinogen oxidase; VP; PPO; V290M
儲(chǔ) 存: 冷凍(-20℃)
相關(guān)類別: 抗原
概 述:
Fusion protein corresponding to a region derived from 278-477 amino acids of human PPOX |
Full name: |
protoporphyrinogen oxidase |
Synonyms: |
VP; PPO; V290M |
Swissprot: |
P50336 |
Gene Accession: |
BC002357 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified. |