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  • RRP8抗原（重組蛋白）

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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW18412
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫(kù)存：90
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中文名稱(chēng)：RRP8抗原（重組蛋白）

英文名稱(chēng)： RRP8 Antigen (Recombinant Protein)

別      名： NML; KIAA0409

儲(chǔ)      存： 冷凍（-20℃）

相關(guān)類(lèi)別： 抗原

概      述：

Fusion protein corresponding to a region derived from 257-456 amino acids of human RRP8


技術(shù)規(guī)格：

Full name:

ribosomal RNA processing 8

Synonyms:

NML; KIAA0409

Swissprot:

O43159

Gene Accession:

BC001071

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.