兔抗DUSP9多克隆抗體

Background:

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases, is expressed only in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus.

Applications:

ELISA, IHC

Name of antibody:

DUSP9

Immunogen:

Synthetic peptide of human DUSP9

Full name:

dual specificity phosphatase 9

Synonyms：

MKP4; MKP-4

SwissProt:

Q99956

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human prostate cancer and Human ovarian cancer

IHC Recommend dilution:

10-50