兔抗E2F4多克隆抗體

Background:

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two.

Applications:

ELISA, IHC

Name of antibody:

E2F4

Immunogen:

Synthetic peptide of human E2F4

Full name:

E2F transcription factor 4, p107/p130-binding

Synonyms：

E2F-4

SwissProt:

Q16254

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human thyroid cancer and Human liver cancer

IHC Recommend dilution:

50-200