兔抗MITF(Ab-18073) 多克隆抗體

Background:

This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome.

Applications:

WB, IHC, IF

Name of antibody:

MITF(Ab-180/73)

Immunogen:

Synthesized non-phosphopeptide derived from human MITF around the phosphorylation site of serine 180/73 (P-N-S(p)-P-M).

Full name:

microphthalmia-associated transcription factor

Synonyms：

MI; WS2; CMM8; WS2A; bHLHe32

SwissProt:

O75030

IHC positive control:

Human skin tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

59 kDa

WB Positive control:

HepG2 cells and COLO205 lysates

WB Recommended dilution:

500-3000

IF positive control:

Hela cells

IF Recommend dilution:

100-500