兔抗ELOC多克隆抗體

Background:

This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified.

Applications:

ELISA, IHC

Name of antibody:

ELOC

Immunogen:

Fusion protein of human ELOC

Full name:

elongin C

Synonyms:

SIII; TCEB1

SwissProt:

Q15369

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human breast cancerHuman ovarian cancer

IHC Recommend dilution:

50-300