兔抗PC多克隆抗體

Background:

This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene.

Applications:

ELISA, WB

Name of antibody:

PC

Immunogen:

Fusion protein of human PC

Full name:

Pyruvate carboxylase

Synonyms：

PCB

SwissProt:

P11498

ELISA Recommended dilution:

1000-2000

WB Predicted band size:

130 kDa

WB Positive control:

Hela cells and human liver cancer tissue

WB Recommended dilution:

200-1000