購(gòu)物車
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021-54845833/15800441009
中文名稱： 兔抗PLN多克隆抗體
英文名稱： Anti-PLN rabbit polyclonal antibody
抗 原： PLN
別 名： phospholamban; PLB; CMD1P; CMH18
相關(guān)類別： 一抗
儲(chǔ) 存： 冷凍（-20℃）
宿 主： Rabbit
反應(yīng)種屬： Human, Mouse, Rat
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
PLN |
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Immunogen: |
Synthetic peptide of human PLN |
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Full name: |
phospholamban |
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Synonyms: |
PLB; CMD1P; CMH18 |
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SwissProt: |
P26678 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human brain |
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IHC Recommend dilution: |
25-50 |
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WB Predicted band size: |
6 kDa |
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WB Positive control: |
Mouse heart tissue, Human heart tissue, Rat heart tissue lysates |
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WB Recommended dilution: |
500-2000 |
