購(gòu)物車
幫助
021-54845833/15800441009
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Background: |
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
TBX1 |
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Immunogen: |
Synthetic peptide of human TBX1 |
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Full name: |
T-box 1 |
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Synonyms: |
DGS; TGA; VCF; CAFS; CTHM; DGCR; DORV; VCFS; TBX1C; CATCH22 |
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SwissProt: |
O43435 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human liver cancer |
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IHC Recommend dilution: |
25-100 |
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WB Predicted band size: |
43 kDa |
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WB Positive control: |
293T and Hela cell lysates |
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WB Recommended dilution: |
500-2000 |
