兔抗BRAF(Phospho-Thr753)多克隆抗體

Background:

This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq, Jul 2008]

Applications:

WB

Name of antibody:

BRAF(Phospho-Thr753)

Immunogen:

Peptide sequence around phosphorylation site of threonine 753 (P-K-T(p)-P-L) derived from Human B-Raf.

Full name:

B-Raf proto-oncogene, serine/threonine kinase

Synonyms：

NS7; BRAF1; RAFB1; B-RAF1

SwissProt:

P15056

WB Predicted band size:

84 kDa

WB Positive control:

K562 cells lysates treated with EGF

WB Recommended dilution:

500-1000