兔抗CARD16多克隆抗體

Background:

Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.

Applications:

ELISA, WB, IHC

Name of antibody:

CARD16

Immunogen:

Synthetic peptide of human CARD16

Full name:

caspase recruitment domain family member 16

Synonyms:

COP; COP1; PSEUDO-ICE

SwissProt:

Q5EG05

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer

IHC Recommend dilution:

40-200

WB Predicted band size:

23 kDa

WB Positive control:

Human placenta tissue lysate

WB Recommended dilution:

500-2000