兔抗CBX3多克隆抗體

Background:

At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks.

Applications:

ELISA, WB, IHC

Name of antibody:

CBX3

Immunogen:

Synthetic peptide of human CBX3

Full name:

chromobox homolog 3

Synonyms:

HECH; HP1-GAMMA; HP1Hs-gamma

SwissProt:

Q13185

IHC positive control:

Human gastric cancer and human brain

IHC Recommend dilution:

50-200

WB Predicted band size:

21 kDa

WB Positive control:

A375 and Raji cells, human fetal brain tissue

WB Recommended dilution:

500-2000