兔抗CCND3多克隆抗體

Background:

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb.

Applications:

ELISA, IHC

Name of antibody:

CCND3

Immunogen:

Synthetic peptide of human CCND3

Full name:

cyclin D3

SwissProt:

P30281

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human liver cancer and Human brain

IHC Recommend dilution:

50-200