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  • SELENOP 抗原（重組蛋白）

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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW4815
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫(kù)存：20
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中文名稱： SELENOP 抗原（重組蛋白）

英文名稱： SELENOP Antigen (Recombinant Protein)

相關(guān)類別： 抗原

儲(chǔ)     存： 冷凍（-20℃） 避光

概     述

Fusion protein corresponding to a region derived from 62-211 amino acids of human SELENOP

技術(shù)規(guī)格

Full name:

selenoprotein P

Synonyms:

SeP; SELP; SEPP; SEPP1

Swissprot:

P49908

Gene Accession:

BC058919

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in human), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. The use of alternative polyadenylation sites, one located in between the two SECIS elements, results in two populations of mRNAs containing either both (predominant) or just the upstream SECIS element (PMID:27881738). Alternatively spliced transcript variants have also been found for this gene.