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  • SKIL 抗原(重組蛋白)

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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW4929
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫存:20
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中文名稱: SKIL 抗原(重組蛋白)

英文名稱: SKIL Antigen (Recombinant Protein)

別     名: SKI-like proto-oncogene; SNO; SnoA; SnoI; SnoN

儲(chǔ)     存: 冷凍(-20℃)

相關(guān)類別:抗原

概     述

Fusion protein corresponding to C terminal 235 amino acids of human SKIL

技術(shù)規(guī)格

Full name:

SKI-like proto-oncogene

Synonyms:

SNO; SnoA; SnoI; SnoN

Swissprot:

P12757

Gene Accession:

BC059386

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene.