兔抗ADAM15多克隆抗體

Background:

The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.

Applications:

ELISA, WB, IHC

Name of antibody:

ADAM15

Immunogen:

Fusion protein of human ADAM15

Full name:

ADAM metallopeptidase domain 15

Synonyms:

MDC15

SwissProt:

Q13444

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human tonsil and Human prostate cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

93 kDa

WB Positive control:

Jurkat, PC-3, HepG2 and NIH/3T3 cell lysates

WB Recommended dilution:

500-2000