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  • UNC45B 抗原(重組蛋白)

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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW6234
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫(kù)存:20
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中文名稱: UNC45B 抗原(重組蛋白)

英文名稱: UNC45B Antigen (Recombinant Protein)

別     名
unc-45 myosin chaperone B; CMYA4; UNC45; CTRCT43; SMUNC45; UNC-45B

相關(guān)類別: 抗原

儲(chǔ)     存 冷凍(-20℃)

概     述

Fusion protein corresponding to a region derived from 732-931 amino acids of human UNC45B

技術(shù)規(guī)格

Full name:

unc-45 myosin chaperone B

Synonyms:

CMYA4; UNC45; CTRCT43; SMUNC45; UNC-45B

Swissprot:

Q8IWX7

Gene Accession:

BC101063

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants.