購(gòu)物車(chē)
幫助
021-54845833/15800441009
中文名稱(chēng)：小鼠抗BTRC單克隆抗體
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Background: |
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar |
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Applications: |
WB, IF, FC |
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Name of antibody: |
BTRC |
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Immunogen: |
Fusion protein of human BTRC |
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Full name: |
beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC), transcript variant 1 |
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Synonyms: |
BETA-TRCP; betaTrCP; bTrCP; bTrCP1; FBW1A; FBXW1; FBXW1A; FWD1 |
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SwissProt: |
Q9Y297 |
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WB Predicted band size: |
69 kDa |
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WB Positive control: |
NIH/3T3 cell lysate |
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WB Recommended dilution: |
200-1000 |
