小鼠抗CDKN1B單克隆抗體

Background:

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).

Applications:

WB

Name of antibody:

CDKN1B

Immunogen:

Fusion protein of human CDKN1B

Full name:

cyclin dependent kinase inhibitor 1B

Synonyms:

KIP1; MEN4; CDKN4; MEN1B; P27KIP1

SwissProt:

P46527

WB Predicted band size:

22 kDa

WB Positive control:

A549 and 3T3 cell lysates

WB Recommended dilution:

200-1000