小鼠抗CKMT2單克隆抗體

Background:

Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Sarcomeric mitochondrial creatine kinase has 80% homology with the coding exons of ubiquitous mitochondrial creatine kinase. This gene contains sequences homologous to several motifs that are shared among some nuclear genes encoding mitochondrial proteins and thus may be essential for the coordinated activation of these genes during mitochondrial biogenesis. Three transcript variants encoding the same protein have been found for this gene.

Applications:

WB

Name of antibody:

CKMT2

Immunogen:

Fusion protein of human CKMT2

Full name:

creatine kinase, mitochondrial 2

Synonyms:

SMTCK

SwissProt:

P17540

WB Predicted band size:

48 kDa

WB Positive control:

Rat brain tissue lysate

WB Recommended dilution:

1000-5000