購(gòu)物車
幫助
021-54845833/15800441009
中文名稱 : 小鼠抗MAP2K3單克隆抗體
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Background: |
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]. |
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Applications: |
WB, IHC, IF |
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Name of antibody: |
MAP2K3 |
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Immunogen: |
Fusion protein of human MAP2K3 |
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Full name: |
mitogen-activated protein kinase kinase 3 (MAP2K3), transcript variant B |
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Synonyms: |
MAPKK3; MEK3; MKK3; PRKMK3; SAPKK-2; SAPKK2 |
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SwissProt: |
P46734 |
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IHC positive control: |
adenocarcinoma of human ovary tissue and adenocarcinoma of human endometrium tissue |
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IHC Recommend dilution: |
30-150 |
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WB Predicted band size: |
39 kDa |
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WB Positive control: |
HepG2, Hela, SVT2, A549, COS7, Jurkat, MDCK, MCF-7 cell lysates |
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WB Recommended dilution: |
500-2000 |
