兔抗COPS2多克隆抗體

Background:

Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.

Applications:

WB, IF

Name of antibody:

COPS2

Immunogen:

Synthesized peptide derived from internal of human COPS2.

Full name:

COP9 signalosome subunit 2

Synonyms：

CSN2; SGN2; ALIEN; TRIP15

SwissProt:

P61201

WB Predicted band size:

52 kDa

WB Positive control:

COS7 cells and COLO205 lysates

WB Recommended dilution:

500-3000

IF positive control:

A549 cells

IF Recommend dilution:

100-500