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中文名稱： 兔抗Mapt (phospho-Ser416)多克隆抗體
英文名稱： Anti-Mapt (phospho-Ser416) rabbit polyclonal antibody別 名： pTau; Mtapt; RNPTAU
相關(guān)類別： 一抗
儲(chǔ) 存： 冷凍（-20℃） 避光
宿 主： Rabbit
抗 原： Mapt (phospho-Ser416)
反應(yīng)種屬： Human, Mouse, Rat
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5 (1-2). Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation of Ser396 by GSK-3 or CDK5 destabilizes microtubules in Alzheimer's disease. Furthermore, inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies (1,3). |
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Applications: |
WB |
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Name of antibody: |
Mapt (phospho-Ser416) |
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Immunogen: |
Synthetic peptide of Rat Mapt (phospho-Ser416) |
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Full name: |
microtubule-associated protein tau (phospho-Ser416) |
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Synonyms： |
pTau; Mtapt; RNPTAU |
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SwissProt: |
P19332 |
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WB Predicted band size: |
48 kDa; 62 kDa; 78 kDa |
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WB Positive control: |
Rat brain, Rat hippocampus and Mouse brain tissue |
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WB Recommended dilution: |
500-1000 |
