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細(xì)胞系

細(xì)胞庫(kù)

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菌株

生化試劑

病理染色液

科研抗體

TPMT 抗原（重組蛋白）

規(guī)格：

數(shù)量：

購(gòu)買(mǎi)數(shù)量

價(jià)格：￥

中文名稱(chēng)：TPMT 抗原（重組蛋白）

英文名稱(chēng)： TPMT Antigen (Recombinant Protein)

別名： thiopurine S-methyltransferase; TPMTD

儲(chǔ) 存： 冷凍（-20℃）

相關(guān)類(lèi)別： 抗原

概述：

Fusion protein corresponding to a region derived from 1-245 amino acids of human TPMT

技術(shù)規(guī)格：

Full name:	thiopurine S-methyltransferase
Synonyms:	TPMTD
Swissprot:	P51580
Gene Accession:	BC005339
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.

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