兔抗DUSP11多克隆抗體

Background:

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism.

Applications:

ELISA, IHC

Name of antibody:

DUSP11

Immunogen:

Full length fusion protein

Full name:

dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)

Synonyms：

PIR1

SwissProt:

O75319

ELISA Recommended dilution:

2000-10000

IHC positive control:

Human liver cancer

IHC Recommend dilution:

30-150