購物車
幫助
021-54845833/15800441009
中文名稱： 兔抗Rasgrf1(Phospho-Ser916) 多克隆抗體
英文名稱： Anti-Rasgrf1(Phospho-Ser916) rabbit polyclonal antibody
別 名： GNRP; GRF1; CDC25; GRF55; CDC25L; H-GRF55; PP13187; ras-GRF1
相關(guān)類別： 一抗
儲 存： 冷凍（-20℃） 避光
宿 主： Rabbit
抗 原： Rasgrf1(Phospho-Ser916)
反應種屬： Human Mouse
標 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
|
Background: |
Ras activity is regulated by GAP (GTPase activating proteins) and GEFs (guanine nucleotide exchange factors). Ras-GRF1 (also known as CDC25Mm) is neuronal RasGEF and is regulated by heterotrimeric G proteins and calcium influx . Binding to calmodulin and phosphorylation stimulate Ras-GRF1 activity. Multiple PKA phosphorylation sites on Ras-GRF have been identified. Phosphorylation on the two major sites, Ser54 and Ser822, inhibits Ras-GRF activity. Carbachol (a muscarinic agonist)-induced phosphorylation on Ser916 is essential but not sufficient for maximal Ras-GRF activity. |
|
Applications: |
IHC |
|
Name of antibody: |
Rasgrf1(Phospho-Ser916) |
|
Immunogen: |
Peptide sequence around phosphorylation site of Serine 916(N-E-G(p)-T P) derived from Human Ras-GRF1. |
|
Full name: |
Ras protein-specific guanine nucleotide-releasing factor 1 |
|
Synonyms： |
GNRP; GRF1; CDC25; GRF55; CDC25L; H-GRF55; PP13187; ras-GRF1 |
|
SwissProt: |
Q13972 |
|
IHC positive control: |
Human brain tissue |
|
IHC Recommend dilution: |
50-100 |
