兔抗MYSM1多克隆抗體

Background:

Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Binds histones

Applications:

ELISA, IHC

Name of antibody:

MYSM1

Immunogen:

Synthetic peptide of human MYSM1

Full name:

Myb-like, SWIRM and MPN domains 1

Synonyms：

2ADUB, 2A-DUB, RP4-592A1.1

SwissProt:

Q5VVJ2

ELISA Recommended dilution:

2000-10000

IHC positive control:

Human ovarian cancer

IHC Recommend dilution:

50-200