購(gòu)物車
幫助
021-54845833/15800441009
中文名稱：兔抗CCN4多克隆抗體
英文名稱： Anti-CCN4 rabbit polyclonal antibody
別 名： cellular communication network factor 4; WISP1; WI
相關(guān)類別： 一抗
儲(chǔ) 存： 冷凍（-20℃）
宿 主： Rabbit
抗 原： CCN4
反應(yīng)種屬： Human, Mouse, Rat
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
|
Background: |
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011] |
|
Applications: |
ELISA, IHC |
|
Name of antibody: |
CCN4 |
|
Immunogen: |
Synthetic peptide of human CCN4 |
|
Full name: |
cellular communication network factor 4 |
|
Synonyms: |
WISP1; WISP1c; WISP1i; WISP1tc; WISP1-OT1; WISP1-UT1 |
|
SwissProt: |
O95388 |
|
IHC positive control: |
Human esophagus cancer |
|
IHC Recommend dilution: |
25-100 |
