兔抗CDK5(Phospho-Tyr15)多克隆抗體

Background:

Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM.

Applications:

WB

Name of antibody:

CDK5(Phospho-Tyr15)

Immunogen:

Peptide sequence around phosphorylation site of Tyrosine15 (G-T-Y(p)-G-T) derived from Human CDK5.

Full name:

cyclin-dependent kinase 5

Synonyms：

PSSALRE

SwissProt:

Q00535

WB Predicted band size:

33 kDa

WB Positive control:

COS7 cells lysates treated with EGF

WB Recommended dilution:

500-1000