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021-54845833/15800441009
中文名稱：兔抗CEND1多克隆抗體
英文名稱： Anti-CEND1 rabbit polyclonal antibody
別 名： cell cycle exit and neuronal differentiation 1; BM88
儲 存： 冷凍（-20℃）
宿 主： Rabbit
抗 原： CEND1
反應(yīng)種屬： Human, Mouse, Rat
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
BM88, also known as CEND1 (cell cycle exit and neuronal differentiation protein 1), is a 149 amino acid protein that belongs to the CEND1 familly. Involved in neuroblastoma cell differentiation, BM88 is a single-pass type IV membrane protein that is neuron specific. It is suggested that BM88 forms a dimer of two identical polypeptides linked by disulfide bridges. BM88 has a central proline-rich region containing four PxxP motifs, which typically bind SRC homology-3 (SH3) domains, as well as a putative C-terminal transmembrane region, and several potential sites for N-glycosylation, myristoylation and phosphorylation. It is also suggested that a novel signaling mechanism exists by which BM88 interferes with calcium release from inositol 1,4,5-trisphosphate-sensitive stores and exerts anti-proliferative and anti-apoptotic functions. BM88 is an important molecular target for HDAC inhibition, and transcription of BM88 is induced by trichostatin-A. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
CEND1 |
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Immunogen: |
Synthetic peptide of human CEND1 |
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Full name: |
cell cycle exit and neuronal differentiation 1 |
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Synonyms: |
BM88 |
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SwissProt: |
Q8N111 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human liver cancer and human prostate cancer |
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IHC Recommend dilution: |
25-100 |
