購物車
幫助
021-54845833/15800441009
標 記 物： Unconjugate
技術規(guī)格
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Background: |
Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262). |
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Applications: |
ELISA, IHC |
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Name of antibody: |
INAVA |
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Immunogen: |
Fusion protein of human INAVA |
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Full name: |
innate immunity activator |
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Synonyms: |
C1orf106 |
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SwissProt: |
Q3KP66 |
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IHC positive control: |
Human liver cancer |
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IHC Recommend dilution: |
50-300 |
