小鼠抗ANKMY2單克隆抗體

Background:

ANKMY2 (ankyrin repeat and MYND domain containing 2) is a 441 amino acid protein that contains three ANK repeats and one MYND-type zinc finger. Encoded by a gene that maps to human chromosome 7p21.1, ANKMY2 is conserved in chimpanzee, dog, cow, mouse, chicken, zebrafish, fruit fly, mosquito and Caenorhabditis elegans. Downregulation of ANKMY2, associated with frequent deletions of human chromosome 7p22.1, indicate that ANKMY2 may role a role in the pathogenesis of natural killer (NK)-cell malignancies. ANKMY2 is also upregulated by enforced expression of Hox11, which functions broadly to hinder hemopoiesis, diverts differentiation to an alternative fate and promotes pre-leukaemic states. ANKMY2 may also participate in zinc ion binding, cell adhesion, cellular morphogenesis, neurite outgrowth and human cortical functions.

Applications:

WB, IHC

Name of antibody:

ANKMY2

Immunogen:

Fusion protein of human ANKMY2

Full name:

ankyrin repeat and MYND domain containing 2 (ANKMY2)

Synonyms:

ZMYND20

SwissProt:

Q8IV38

IHC positive control:

adenocarcinoma of human ovary tissue and adenocarcinoma of human breast tissue; human lymph node tissue and human kidney tissue

IHC Recommend dilution:

30-150

WB Predicted band size:

49 kDa

WB Positive control:

HepG2, Hela, SVT2, A549, COS7, Jurkat, MDCK, PC12, MCF-7 cell lysates

WB Recommended dilution:

200-1000