兔抗ADAMTS5多克隆抗體

Background:

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis.

Applications:

ELISA, WB, IHC

Name of antibody:

ADAMTS5

Immunogen:

Synthetic peptide of human ADAMTS5

Full name:

ADAM metallopeptidase with thrombospondin type 1 motif 5

Synonyms:

ADMP-2; ADAM-TS5; ADAMTS-5; ADAMTS11; ADAM-TS 5; ADAMTS-11; ADAM-TS 11

SwissProt:

Q9UNA0

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer

IHC Recommend dilution:

50-100

WB Predicted band size:

102 kDa

WB Positive control:

Hela cell and Human placenta tissue lysates

WB Recommended dilution:

500-2000