兔抗HUWE1多克隆抗體

Background:

This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic mental retardation.

Applications:

ELISA, IHC

Name of antibody:

HUWE1

Immunogen:

Synthetic peptide of human HUWE1

Full name:

HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase

Synonyms:

MULE; Ib772; LASU1; UREB1; HECTH9; URE-B1; ARF-BP1; HSPC272

SwissProt:

Q7Z6Z7

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human esophagus cancer and human lung cancer

IHC Recommend dilution:

10-50