兔抗ABCD2多克隆抗體

Background:

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis.

Applications:

ELISA, IHC

Name of antibody:

ABCD2

Immunogen:

Synthetic peptide of human ABCD2

Full name:

ATP-binding cassette, sub-family D (ALD), member 2

Synonyms：

ALDR; ABC39; ALDL1; ALDRP; hALDR

SwissProt:

Q9UBJ2

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human ovarian cancer and Human thyroid cancer

IHC Recommend dilution:

25-100