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中文名稱：兔抗SENP6多克隆抗體
英文名稱： Anti-SENP6 rabbit polyclonal antibody
別 名： SUMO1/sentrin specific peptidase 6; SSP1; SUSP1
相關類別： 一抗
儲 存： 冷凍（-20℃）
宿 主： Rabbit
抗 原： SENP6
反應種屬： Human
標記物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. |
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Applications: |
ELISA, WB |
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Name of antibody: |
SENP6 |
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Immunogen: |
Synthetic peptide of human SENP6 |
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Full name: |
SUMO1/sentrin specific peptidase 6 |
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Synonyms: |
SSP1; SUSP1 |
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SwissProt: |
Q9GZR1 |
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ELISA Recommended dilution: |
5000-10000 |
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WB Predicted band size: |
126 kDa |
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WB Positive control: |
Human prostate tissue lysate |
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WB Recommended dilution: |
500-2000 |
