兔抗ABCC5多克隆抗體

Background:

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.

Applications:

ELISA, WB, IHC

Name of antibody:

ABCC5

Immunogen:

Synthetic peptide of human ABCC5

Full name:

ATP-binding cassette, sub-family C

Synonyms：

MRP5, SMRP, ABC33, MOATC, MOAT-C, pABC11, EST277145

SwissProt:

O15440

ELISA Recommended dilution:

2000-10000

IHC positive control:

Human ovarian cancer and Human lung cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

161 kDa

WB Positive control:

Mouse heart tissue

WB Recommended dilution:

1000-5000