兔抗HIF1AN多克隆抗體

Background:

Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively.

Applications:

ELISA, WB, IHC

Name of antibody:

HIF1AN

Immunogen:

Full length fusion protein

Full name:

hypoxia inducible factor 1, alpha subunit inhibitor

Synonyms：

FIH1

SwissProt:

Q9NWT6

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human gastric cancer and human tonsil

IHC Recommend dilution:

25-100

WB Predicted band size:

40 kDa

WB Positive control:

Human fetal muscle tissue

WB Recommended dilution:

200-1000