兔抗TGFB2多克隆抗體

Background:

This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified.

Applications:

ELISA, IHC

Name of antibody:

TGFB2

Immunogen:

Synthetic peptide of human TGFB2

Full name:

transforming growth factor, beta 2

Synonyms：

LDS4; TGF-beta2

SwissProt:

P61812

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human liver cancer and Human lung cancer

IHC Recommend dilution:

25-100